@article{df50a3afaa0e44b58e895909ed4e8b1a,
title = "Carbamazepine up-regulates the binding of [3H]PK 11195 to platelets of epileptic patients",
abstract = "The maximal number of binding sites (Bmax) and the equilibrium dissociation constant (KD) values for [3H]PK 11195 binding were determined in the platelet membranes of epileptic patients before and after 4 weeks of carbamazepine (CBZ) treatment, as well as in healthy controls. There was a decrease of 17.1% in the Bmax value of patients before treatment as compared to the controls whereas an increase of 50.3% was observed in CBZ-treated patients as compared to their pretreatment values. The up-regulatory effect of CBZ on peripheral benzodiazepine receptors was not accompanied by alterations in KD values.",
keywords = "Benzodiazepine receptors (peripheral type), Carbamazepine, Epilepsy, [H]PK 11195",
author = "Abraham Weizman and Zehava Tanne and Leon Karp and Yoseph Martfeld and Sam Tyano and Moshe Gavish",
note = "Funding Information: This work was supported by a grant from the Israel Ministry of Health. We thank Frank Vocci for his helpful suggestions and Miss Ruth Singer for typing the manuscript.",
year = "1987",
month = sep,
day = "23",
doi = "10.1016/0014-2999(87)90567-X",
language = "אנגלית",
volume = "141",
pages = "471--474",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier B.V.",
number = "3",
}