Carbamazepine up-regulates the binding of [3H]PK 11195 to platelets of epileptic patients

Abraham Weizman, Zehava Tanne, Leon Karp, Yoseph Martfeld, Sam Tyano, Moshe Gavish

Research output: Contribution to journalArticlepeer-review

Abstract

The maximal number of binding sites (Bmax) and the equilibrium dissociation constant (KD) values for [3H]PK 11195 binding were determined in the platelet membranes of epileptic patients before and after 4 weeks of carbamazepine (CBZ) treatment, as well as in healthy controls. There was a decrease of 17.1% in the Bmax value of patients before treatment as compared to the controls whereas an increase of 50.3% was observed in CBZ-treated patients as compared to their pretreatment values. The up-regulatory effect of CBZ on peripheral benzodiazepine receptors was not accompanied by alterations in KD values.

Original languageEnglish
Pages (from-to)471-474
Number of pages4
JournalEuropean Journal of Pharmacology
Volume141
Issue number3
DOIs
StatePublished - 23 Sep 1987

Keywords

  • Benzodiazepine receptors (peripheral type)
  • Carbamazepine
  • Epilepsy
  • [H]PK 11195

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