CAR T-cell therapy for the management of refractory/relapsed high-grade B-cell lymphoma: a practical overview

Mohamad Mohty; Remy Dulery; Jordan Gauthier; Florent Malard; Eolia Brissot; Mahmoud Aljurf; Ali Bazarbachi; Christian Chabanon; Mohamed A. Kharfan-Dabaja; Bipin N. Savani; He Huang; Saad S. Kenderian; Miguel Angel Perales; Ibrahim Yakoub-Agha; Arnon Nagler

doi:10.1038/s41409-020-0892-7

CAR T-cell therapy for the management of refractory/relapsed high-grade B-cell lymphoma: a practical overview

Mohamad Mohty^*, Remy Dulery, Jordan Gauthier, Florent Malard, Eolia Brissot, Mahmoud Aljurf, Ali Bazarbachi, Christian Chabanon, Mohamed A. Kharfan-Dabaja, Bipin N. Savani, He Huang, Saad S. Kenderian, Miguel Angel Perales, Ibrahim Yakoub-Agha, Arnon Nagler

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Review article › peer-review

Abstract

The goal of this review is to firstly address the concept of chimeric antigen receptor T-cell (CAR T-cell) therapy and where it fits in the evolving landscape of the management of patients with refractory/relapsed diffuse large B-cell lymphoma. The recognition of the indications for CAR T-cell therapy for patients with aggressive B-cell lymphoma will be discussed, including a review of the algorithms and selection criteria for CAR T-cell therapy and finally, the role of bridging therapy and the timing of CAR T-cell therapy in augmenting chances of a successful outcome.

Original language	English
Pages (from-to)	1525-1532
Number of pages	8
Journal	Bone Marrow Transplantation
Volume	55
Issue number	8
DOIs	https://doi.org/10.1038/s41409-020-0892-7
State	Published - 1 Aug 2020

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Mohty, M., Dulery, R., Gauthier, J., Malard, F., Brissot, E., Aljurf, M., Bazarbachi, A., Chabanon, C., Kharfan-Dabaja, M. A., Savani, B. N., Huang, H., Kenderian, S. S., Perales, M. A., Yakoub-Agha, I., & Nagler, A. (2020). CAR T-cell therapy for the management of refractory/relapsed high-grade B-cell lymphoma: a practical overview. Bone Marrow Transplantation, 55(8), 1525-1532. https://doi.org/10.1038/s41409-020-0892-7

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title = "CAR T-cell therapy for the management of refractory/relapsed high-grade B-cell lymphoma: a practical overview",

abstract = "The goal of this review is to firstly address the concept of chimeric antigen receptor T-cell (CAR T-cell) therapy and where it fits in the evolving landscape of the management of patients with refractory/relapsed diffuse large B-cell lymphoma. The recognition of the indications for CAR T-cell therapy for patients with aggressive B-cell lymphoma will be discussed, including a review of the algorithms and selection criteria for CAR T-cell therapy and finally, the role of bridging therapy and the timing of CAR T-cell therapy in augmenting chances of a successful outcome.",

author = "Mohamad Mohty and Remy Dulery and Jordan Gauthier and Florent Malard and Eolia Brissot and Mahmoud Aljurf and Ali Bazarbachi and Christian Chabanon and Kharfan-Dabaja, {Mohamed A.} and Savani, {Bipin N.} and He Huang and Kenderian, {Saad S.} and Perales, {Miguel Angel} and Ibrahim Yakoub-Agha and Arnon Nagler",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive licence to Springer Nature Limited.",

year = "2020",

month = aug,

day = "1",

doi = "10.1038/s41409-020-0892-7",

language = "אנגלית",

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Mohty, M, Dulery, R, Gauthier, J, Malard, F, Brissot, E, Aljurf, M, Bazarbachi, A, Chabanon, C, Kharfan-Dabaja, MA, Savani, BN, Huang, H, Kenderian, SS, Perales, MA, Yakoub-Agha, I & Nagler, A 2020, 'CAR T-cell therapy for the management of refractory/relapsed high-grade B-cell lymphoma: a practical overview', Bone Marrow Transplantation, vol. 55, no. 8, pp. 1525-1532. https://doi.org/10.1038/s41409-020-0892-7

TY - JOUR

T1 - CAR T-cell therapy for the management of refractory/relapsed high-grade B-cell lymphoma

T2 - a practical overview

AU - Mohty, Mohamad

AU - Dulery, Remy

AU - Gauthier, Jordan

AU - Malard, Florent

AU - Brissot, Eolia

AU - Aljurf, Mahmoud

AU - Bazarbachi, Ali

AU - Chabanon, Christian

AU - Kharfan-Dabaja, Mohamed A.

AU - Savani, Bipin N.

AU - Huang, He

AU - Kenderian, Saad S.

AU - Perales, Miguel Angel

AU - Yakoub-Agha, Ibrahim

AU - Nagler, Arnon

PY - 2020/8/1

Y1 - 2020/8/1

N2 - The goal of this review is to firstly address the concept of chimeric antigen receptor T-cell (CAR T-cell) therapy and where it fits in the evolving landscape of the management of patients with refractory/relapsed diffuse large B-cell lymphoma. The recognition of the indications for CAR T-cell therapy for patients with aggressive B-cell lymphoma will be discussed, including a review of the algorithms and selection criteria for CAR T-cell therapy and finally, the role of bridging therapy and the timing of CAR T-cell therapy in augmenting chances of a successful outcome.

AB - The goal of this review is to firstly address the concept of chimeric antigen receptor T-cell (CAR T-cell) therapy and where it fits in the evolving landscape of the management of patients with refractory/relapsed diffuse large B-cell lymphoma. The recognition of the indications for CAR T-cell therapy for patients with aggressive B-cell lymphoma will be discussed, including a review of the algorithms and selection criteria for CAR T-cell therapy and finally, the role of bridging therapy and the timing of CAR T-cell therapy in augmenting chances of a successful outcome.

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AN - SCOPUS:85083883799

SN - 0268-3369

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EP - 1532

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

IS - 8

ER -

CAR T-cell therapy for the management of refractory/relapsed high-grade B-cell lymphoma: a practical overview

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