CAR-T cell manufacturing failures and out-of-specification products in the real-world setting: A survey from the EBMT cellular therapy and immunobiology working party

Nina Worel; Jarl E. Mooyaart; Jorinde D. Hoogenboom; Michael Daskalakis; Jean Jacques Tudesq; Ron Ram; Vladan Vucinic; Stefania Bramanti; Lucía López Corral; Emma Nicholson; Robert Zeiser; Friedrich Stölzel; Eugenio Galli; Simona Pagliuca; Eva Wagner-Drouet; Friso Calkoen; Christian Chabannon; Florent Malard; Annalisa Ruggeri; Jürgen Kuball

doi:10.1038/s41409-025-02623-0

CAR-T cell manufacturing failures and out-of-specification products in the real-world setting: A survey from the EBMT cellular therapy and immunobiology working party

Nina Worel^*
, Jarl E. Mooyaart
, Jorinde D. Hoogenboom
, Michael Daskalakis
, Jean Jacques Tudesq
, Ron Ram
, Vladan Vucinic
, Stefania Bramanti
, Lucía López Corral
, Emma Nicholson
, Robert Zeiser
, Friedrich Stölzel
, Eugenio Galli
, Simona Pagliuca
, Eva Wagner-Drouet
, Friso Calkoen
, Christian Chabannon
, Florent Malard
, Annalisa Ruggeri
, Jürgen Kuball

^*Corresponding author for this work

Medical University of Vienna
EBMT Leiden Study Unit
University of Bern
CHU Montpellier
Tel Aviv Sourasky Medical Center
Leipzig University
IRCCS Istituto Clinico Humanitas - Rozzano (Milano)
Hospital Clínico Universitario de Salamanca
Royal Marsden NHS Foundation Trust
University of Freiburg
University Medical Center Schleswig- Holstein
Catholic University of Sacred Heart
CHU de Nancy
Johannes Gutenberg University Mainz
Utrecht University
Institut Paoli Calmettes
Sorbonne Université
IRCCS San Raffaele Scientific Institute

Research output: Contribution to journal › Letter › peer-review

5 Scopus citations

Original language	English
Pages (from-to)	1184-1186
Number of pages	3
Journal	Bone Marrow Transplantation
Volume	60
Issue number	8
DOIs	https://doi.org/10.1038/s41409-025-02623-0
State	Published - Aug 2025
Externally published	Yes

Funding

Funders
Kite
Gilead Sciences
Janssen and Gilead
Micropalaeontological Society
DSMB
Celgene

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 9 Industry, Innovation, and Infrastructure

Access to Document

10.1038/s41409-025-02623-0

Cite this

Worel, N., Mooyaart, J. E., Hoogenboom, J. D., Daskalakis, M., Tudesq, J. J., Ram, R., Vucinic, V., Bramanti, S., Corral, L. L., Nicholson, E., Zeiser, R., Stölzel, F., Galli, E., Pagliuca, S., Wagner-Drouet, E., Calkoen, F., Chabannon, C., Malard, F., Ruggeri, A., & Kuball, J. (2025). CAR-T cell manufacturing failures and out-of-specification products in the real-world setting: A survey from the EBMT cellular therapy and immunobiology working party. Bone Marrow Transplantation, 60(8), 1184-1186. https://doi.org/10.1038/s41409-025-02623-0

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title = "CAR-T cell manufacturing failures and out-of-specification products in the real-world setting: A survey from the EBMT cellular therapy and immunobiology working party",

author = "Nina Worel and Mooyaart, \{Jarl E.\} and Hoogenboom, \{Jorinde D.\} and Michael Daskalakis and Tudesq, \{Jean Jacques\} and Ron Ram and Vladan Vucinic and Stefania Bramanti and Corral, \{Luc{\'i}a L{\'o}pez\} and Emma Nicholson and Robert Zeiser and Friedrich St{\"o}lzel and Eugenio Galli and Simona Pagliuca and Eva Wagner-Drouet and Friso Calkoen and Christian Chabannon and Florent Malard and Annalisa Ruggeri and J{\"u}rgen Kuball",

year = "2025",

month = aug,

doi = "10.1038/s41409-025-02623-0",

language = "אנגלית",

volume = "60",

pages = "1184--1186",

journal = "Bone Marrow Transplantation",

issn = "0268-3369",

publisher = "Springer Nature",

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Worel, N, Mooyaart, JE, Hoogenboom, JD, Daskalakis, M, Tudesq, JJ, Ram, R, Vucinic, V, Bramanti, S, Corral, LL, Nicholson, E, Zeiser, R, Stölzel, F, Galli, E, Pagliuca, S, Wagner-Drouet, E, Calkoen, F, Chabannon, C, Malard, F, Ruggeri, A & Kuball, J 2025, 'CAR-T cell manufacturing failures and out-of-specification products in the real-world setting: A survey from the EBMT cellular therapy and immunobiology working party', Bone Marrow Transplantation, vol. 60, no. 8, pp. 1184-1186. https://doi.org/10.1038/s41409-025-02623-0

CAR-T cell manufacturing failures and out-of-specification products in the real-world setting: A survey from the EBMT cellular therapy and immunobiology working party. / Worel, Nina; Mooyaart, Jarl E.; Hoogenboom, Jorinde D. et al.
In: Bone Marrow Transplantation, Vol. 60, No. 8, 08.2025, p. 1184-1186.

Research output: Contribution to journal › Letter › peer-review

TY - JOUR

T1 - CAR-T cell manufacturing failures and out-of-specification products in the real-world setting

T2 - A survey from the EBMT cellular therapy and immunobiology working party

AU - Worel, Nina

AU - Mooyaart, Jarl E.

AU - Hoogenboom, Jorinde D.

AU - Daskalakis, Michael

AU - Tudesq, Jean Jacques

AU - Ram, Ron

AU - Vucinic, Vladan

AU - Bramanti, Stefania

AU - Corral, Lucía López

AU - Nicholson, Emma

AU - Zeiser, Robert

AU - Stölzel, Friedrich

AU - Galli, Eugenio

AU - Pagliuca, Simona

AU - Wagner-Drouet, Eva

AU - Calkoen, Friso

AU - Chabannon, Christian

AU - Malard, Florent

AU - Ruggeri, Annalisa

AU - Kuball, Jürgen

PY - 2025/8

Y1 - 2025/8

UR - https://www.scopus.com/pages/publications/105005091594

U2 - 10.1038/s41409-025-02623-0

DO - 10.1038/s41409-025-02623-0

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.letter???

C2 - 40374897

AN - SCOPUS:105005091594

SN - 0268-3369

VL - 60

SP - 1184

EP - 1186

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

IS - 8

ER -

CAR-T cell manufacturing failures and out-of-specification products in the real-world setting: A survey from the EBMT cellular therapy and immunobiology working party

Funding

UN SDGs

Access to Document

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Cite this