TY - JOUR
T1 - Captopril-associated 'pseudocholangitis'
T2 - A case report and review of the literature
AU - Nissan, Aviram
AU - Spira, Ram M.
AU - Seror, Dan
AU - Ackerman, Zvi
PY - 1996
Y1 - 1996
N2 - Captopril, a competitive inhibitor of angiotensin-converting enzyme, is widely used in the treatment of hypertension and heart failure. Captopril is known to be associated with dermatologic, hematologic, and pulmonary adverse effects. However, hepatotoxicity is extremely rare. A patient with severe cholestatic jaundice induced by captopril is presented. On admission to the hospital, the patient was diagnosed and treated as having cholangitis. Review of the literature showed similar occurrences in other patients. Patients treated with captopril who develop 'atypical cholangitis' should be suspected of having captopril-associated liver damage.
AB - Captopril, a competitive inhibitor of angiotensin-converting enzyme, is widely used in the treatment of hypertension and heart failure. Captopril is known to be associated with dermatologic, hematologic, and pulmonary adverse effects. However, hepatotoxicity is extremely rare. A patient with severe cholestatic jaundice induced by captopril is presented. On admission to the hospital, the patient was diagnosed and treated as having cholangitis. Review of the literature showed similar occurrences in other patients. Patients treated with captopril who develop 'atypical cholangitis' should be suspected of having captopril-associated liver damage.
UR - http://www.scopus.com/inward/record.url?scp=0029901595&partnerID=8YFLogxK
U2 - 10.1001/archsurg.1996.01430180096021
DO - 10.1001/archsurg.1996.01430180096021
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C2 - 8645078
AN - SCOPUS:0029901595
SN - 0004-0010
VL - 131
SP - 670
EP - 671
JO - Archives of Surgery
JF - Archives of Surgery
IS - 6
ER -