Candidate gene analysis in Israeli soldiers with stress fractures

Ran Yanovich*, Eitan Friedman, Roni Milgrom, Bernice Oberman, Laurence Freedman, Daniel S. Moran

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

To investigate the association of polymorphisms within candidate genes which we hypothesized may contribute to stress fracture predisposition, a case-control, cross-sectional study design was employed. Genotyping 268 Single Nucleotide Polymorphisms-SNPs within 17 genes in 385 Israeli young male and female recruits (182 with and 203 without stress fractures). Twenty-five polymorphisms within 9 genes (NR3C1, ANKH, VDR, ROR2, CALCR, IL6, COL1A2, CBG, and LRP4) showed statistically significant differences (p < 0.05) in the distribution between stress fracture cases and non stress fracture controls. Seventeen genetic variants were associated with an increased stress fracture risk, and eight variants with a decreased stress fracture risk. None of the SNP associations remained significant after correcting for multiple comparisons (false discovery rate-FDR). Our findings suggest that genes may be involved in stress fracture pathogenesis. Specifically, the CALCR and the VDR genes are intriguing candidates. The putative involvement of these genes in stress fracture predisposition requires analysis of more cases and controls and sequencing the relevant genomic regions, in order to define the specific gene mutations.

Original languageEnglish
Pages (from-to)147-155
Number of pages9
JournalJournal of Sports Science and Medicine
Volume11
Issue number1
StatePublished - Mar 2012

Keywords

  • Bone remodeling
  • Genetic variance
  • Inherited predisposition
  • SNPs
  • Stress fractures

Fingerprint

Dive into the research topics of 'Candidate gene analysis in Israeli soldiers with stress fractures'. Together they form a unique fingerprint.

Cite this