TY - JOUR
T1 - Candida albicans
T2 - A molecular revolution built on lessons from budding yeast
AU - Berman, Judith
AU - Sudbery, Peter E.
N1 - Funding Information:
We thank the many Candida albicans researchers who discussed and provided results before publication. J.B. is supported by the National Institutes of Health, USA, and a Burrough Wellcome Scholar Award. P.E.S. is supported by the Wellcome Trust for Biomedical Research, UK.
PY - 2002/12/1
Y1 - 2002/12/1
N2 - Candida albicans is an opportunistic fungal pathogen that is found in the normal gastrointestinal flora of most healthy humans. However, in immunocompromised patients, blood-stream infections often cause death, despite the use of anti-fungal therapies, The recent completion of the C, albicans genome sequence, the availability of whole-genome microarrays and the development of tools for rapid molecular-genetic manipulations of the C. albicans genome are generating an explosion of information about the intriguing biology of this pathogen and about its mechanisms of virulence. They also reveal the extent of similarities and differences between C, albicans and its benign relative, Saccharomyces cerevisiae.
AB - Candida albicans is an opportunistic fungal pathogen that is found in the normal gastrointestinal flora of most healthy humans. However, in immunocompromised patients, blood-stream infections often cause death, despite the use of anti-fungal therapies, The recent completion of the C, albicans genome sequence, the availability of whole-genome microarrays and the development of tools for rapid molecular-genetic manipulations of the C. albicans genome are generating an explosion of information about the intriguing biology of this pathogen and about its mechanisms of virulence. They also reveal the extent of similarities and differences between C, albicans and its benign relative, Saccharomyces cerevisiae.
UR - http://www.scopus.com/inward/record.url?scp=0036895608&partnerID=8YFLogxK
U2 - 10.1038/nrg948
DO - 10.1038/nrg948
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AN - SCOPUS:0036895608
SN - 1471-0056
VL - 3
SP - 918
EP - 930
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 12
ER -