Candida albicans: A molecular revolution built on lessons from budding yeast

Judith Berman*, Peter E. Sudbery

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Candida albicans is an opportunistic fungal pathogen that is found in the normal gastrointestinal flora of most healthy humans. However, in immunocompromised patients, blood-stream infections often cause death, despite the use of anti-fungal therapies, The recent completion of the C, albicans genome sequence, the availability of whole-genome microarrays and the development of tools for rapid molecular-genetic manipulations of the C. albicans genome are generating an explosion of information about the intriguing biology of this pathogen and about its mechanisms of virulence. They also reveal the extent of similarities and differences between C, albicans and its benign relative, Saccharomyces cerevisiae.

Original languageEnglish
Pages (from-to)918-930
Number of pages13
JournalNature Reviews Genetics
Issue number12
StatePublished - 1 Dec 2002
Externally publishedYes


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