Cancer survivorship and subclinical myocardial damage

Roberta Florido*, Alexandra K. Lee, John W. McEvoy, Ron C. Hoogeveen, Silvia Koton, Mara Z. Vitolins, Chetan Shenoy, Stuart D. Russell, Roger S. Blumenthal, Chiadi E. Ndumele, Christie M. Ballantyne, Corinne E. Joshu, Elizabeth A. Platz, Elizabeth Selvin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Cancer survivors might have an excess risk of cardiovascular disease (CVD) resulting from toxicities of cancer therapies and a high burden of CVD risk factors. We sought to evaluate the association of cancer survivorship with subclinical myocardial damage, as assessed by elevated high-sensitivity cardiac troponin T (hs-cTnT) test results. We included 3,512 participants of the Atherosclerosis Risk in Communities Study who attended visit 5 (2011-2013) and were free of CVD (coronary heart disease, heart failure, or stroke). We used multivariate logistic regression to evaluate the cross-sectional associations of survivorship from any, non-sex-related, and sex-related cancers (e.g., breast, prostate) with elevated hs-cTnT (≥14 ng/L). Of 3,512 participants (mean age, 76 years; 62% women; 21% black), 19% were cancer survivors. Cancer survivors had significantly higher odds of elevated hs-cTnT (OR = 1.26, 95% CI: 1.03, 1.53). Results were similar for survivors of non-sex-related and colorectal cancers, but there was no association between survivorship from breast and prostate cancers and elevated hs-cTnT. Results were similar after additional adjustments for CVD risk factors. Survivors of some cancers might be more likely to have elevated hs-cTnT than persons without prior cancer. The excess burden of subclinical myocardial damage in this population might not be fully explained by traditional CVD risk factors.

Original languageEnglish
Pages (from-to)2188-2195
Number of pages8
JournalAmerican Journal of Epidemiology
Issue number12
StatePublished - 31 Dec 2019


  • ARIC
  • biomarkers
  • cancer
  • cardiovascular disease
  • hs-cTnT


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