Cancer risks among BRCA1 and BRCA2 mutation carriers

E. Levy-Lahad*, E. Friedman

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review


BRCA1 and BRCA2 mutations increase breast and ovarian cancer risks substantially enough to warrant risk reduction surgery, despite variable risk estimates. Underlying this variability are methodological issues, and also complex genetic and nongenetic effects. Although many modifying factors are unidentified, known factors can already be incorporated in individualised risk prediction.

Original languageEnglish
Pages (from-to)11-15
Number of pages5
JournalBritish Journal of Cancer
Issue number1
StatePublished - 15 Jan 2007


  • BRCA1
  • BRCA2
  • Breast cancer
  • Ovarian cancer
  • Penetrance


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