@article{3ca48d70409d463ea17ff5a37f8bd1fa,
title = "Cancer risks among BRCA1 and BRCA2 mutation carriers",
abstract = "BRCA1 and BRCA2 mutations increase breast and ovarian cancer risks substantially enough to warrant risk reduction surgery, despite variable risk estimates. Underlying this variability are methodological issues, and also complex genetic and nongenetic effects. Although many modifying factors are unidentified, known factors can already be incorporated in individualised risk prediction.",
keywords = "BRCA1, BRCA2, Breast cancer, Ovarian cancer, Penetrance",
author = "E. Levy-Lahad and E. Friedman",
note = "Funding Information: Work in ELL{\textquoteright}s laboratory was supported by the Breast Cancer Research Foundation. ELL and EF were supported by the Israel Cancer Association as part of the Israel Breast Cancer Genetics Consortium. We thank Ms Hadassa Hartman for her help in preparing this manuscript.",
year = "2007",
month = jan,
day = "15",
doi = "10.1038/sj.bjc.6603535",
language = "אנגלית",
volume = "96",
pages = "11--15",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Springer Nature",
number = "1",
}
