Cancer risks among BRCA1 and BRCA2 mutation carriers

E. Levy-Lahad, E. Friedman

Research output: Contribution to journalShort surveypeer-review

Abstract

BRCA1 and BRCA2 mutations increase breast and ovarian cancer risks substantially enough to warrant risk reduction surgery, despite variable risk estimates. Underlying this variability are methodological issues, and also complex genetic and nongenetic effects. Although many modifying factors are unidentified, known factors can already be incorporated in individualised risk prediction.

Original languageEnglish
Pages (from-to)11-15
Number of pages5
JournalBritish Journal of Cancer
Volume96
Issue number1
DOIs
StatePublished - 15 Jan 2007

Keywords

  • BRCA1
  • BRCA2
  • Breast cancer
  • Ovarian cancer
  • Penetrance

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