Cancer risks among BRCA1 and BRCA2 mutation carriers

E. Levy-Lahad; E. Friedman

doi:10.1038/sj.bjc.6603535

Cancer risks among BRCA1 and BRCA2 mutation carriers

E. Levy-Lahad, E. Friedman

Clinical Departments

Research output: Contribution to journal › Short survey › peer-review

Abstract

BRCA1 and BRCA2 mutations increase breast and ovarian cancer risks substantially enough to warrant risk reduction surgery, despite variable risk estimates. Underlying this variability are methodological issues, and also complex genetic and nongenetic effects. Although many modifying factors are unidentified, known factors can already be incorporated in individualised risk prediction.

Original language	English
Pages (from-to)	11-15
Number of pages	5
Journal	British Journal of Cancer
Volume	96
Issue number	1
DOIs	https://doi.org/10.1038/sj.bjc.6603535
State	Published - 15 Jan 2007

Keywords

BRCA1
BRCA2
Breast cancer
Ovarian cancer
Penetrance

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.bjc.6603535

Cite this

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note = "Funding Information: Work in ELL{\textquoteright}s laboratory was supported by the Breast Cancer Research Foundation. ELL and EF were supported by the Israel Cancer Association as part of the Israel Breast Cancer Genetics Consortium. We thank Ms Hadassa Hartman for her help in preparing this manuscript.",

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KW - Ovarian cancer

KW - Penetrance

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Cancer risks among BRCA1 and BRCA2 mutation carriers

Abstract

Keywords

UN SDGs

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