Cancer resistance to complement-dependent cytotoxicity (CDC): Problem-oriented research and development

Dana Gancz, Zvi Fishelson

Research output: Contribution to journalReview articlepeer-review

Abstract

The number of anti-cancer antibodies in therapy and in clinical trials is increasing gradually while their curative efficacy remains rather limited due to the resistance of tumor cells to complement-dependent cytotoxicity (CDC). An updated review of the various defense mechanisms complement is confronting when tackling a tumor cell is presented. The mechanisms discussed are: membrane and secreted complement regulatory proteins, heat shock proteins, extracellular proteases and protein kinases, cell surface sialylation and intracellular survival anti-lytic signals. Projected treatment strategies are depicted for each of the complement resistance mechanisms. It is conceivable that the therapeutic capacity of anti-cancer antibodies will be amplified once combined with a reagent that sensitizes the cancer cells to CDC.

Original languageEnglish
Pages (from-to)2794-2800
Number of pages7
JournalMolecular Immunology
Volume46
Issue number14
DOIs
StatePublished - Sep 2009

Keywords

  • Bcl-2
  • CD46
  • CD55
  • CD59
  • Cancer
  • Complement
  • Cytotoxicity
  • Heat shock proteins
  • Mortalin

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