@article{249a14f2c3e24e8fa7e9de3b1e0f1d26,
title = "Cancer microenvironment and genomics: evolution in process",
abstract = "Cancer heterogeneity is a result of genetic mutations within the cancer cells. Their proliferation is not only driven by autocrine functions but also under the influence of cancer microenvironment, which consists of normal stromal cells such as infiltrating immune cells, cancer-associated fibroblasts, endothelial cells, pericytes, vascular and lymphatic channels. The relationship between cancer cells and cancer microenvironment is a critical one and we are just on the verge to understand it on a molecular level. Cancer microenvironment may serve as a selective force to modulate cancer cells to allow them to evolve into more aggressive clones with ability to invade the lymphatic or vascular channels to spread to regional lymph nodes and distant sites. It is important to understand these steps of cancer evolution within the cancer microenvironment towards invasion so that therapeutic strategies can be developed to control or stop these processes.",
keywords = "Cancer evolution, Cancer heterogeneity, Cancer metastasis, Cancer microenvironment",
author = "Leong, {Stanley P.} and Witz, {Isaac P.} and Orit Sagi-Assif and Sivan Izraely and Jonathan Sleeman and Brian Piening and Fox, {Bernard A.} and Bifulco, {Carlo B.} and Rachel Martini and Lisa Newman and Melissa Davis and Sanders, {Lauren M.} and David Haussler and Vaske, {Olena M.} and Marlys Witte",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Nature B.V.",
year = "2022",
month = feb,
doi = "10.1007/s10585-021-10097-9",
language = "אנגלית",
volume = "39",
pages = "85--99",
journal = "Clinical and Experimental Metastasis",
issn = "0262-0898",
publisher = "Springer Netherlands",
number = "1",
}