Cancer Associated Fibroblasts express pro-inflammatory factors in human breast and ovarian tumors

Neta Erez*, Sarah Glanz, Yael Raz, Camilla Avivi, Iris Barshack

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Inflammation has been established in recent years as a hallmark of cancer. Cancer Associated Fibroblasts (CAFs) support tumorigenesis by stimulating angiogenesis, cancer cell proliferation and invasion. We previously demonstrated that CAFs also mediate tumor-enhancing inflammation in a mouse model of skin carcinoma. Breast and ovarian carcinomas are amongst the leading causes of cancer-related mortality in women and cancer-related inflammation is linked with both these tumor types. However, the role of CAFs in mediating inflammation in these malignancies remains obscure. Here we show that CAFs in human breast and ovarian tumors express high levels of the pro-inflammatory factors IL-6, COX-2 and CXCL1, previously identified to be part of a CAF pro-inflammatory gene signature. Moreover, we show that both pro-inflammatory signaling by CAFs and leukocyte infiltration of tumors are enhanced in invasive ductal carcinoma as compared with ductal carcinoma in situ. The pro-inflammatory genes expressed by CAFs are known NF-κB targets and we show that NF-κB is up-regulated in breast and ovarian CAFs. Our data imply that CAFs mediate tumor-promoting inflammation in human breast and ovarian tumors and thus may be an attractive target for stromal-directed therapeutics.

Original languageEnglish
Pages (from-to)397-402
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume437
Issue number3
DOIs
StatePublished - 2 Aug 2013

Keywords

  • Breast cancer
  • CAFs
  • Inflammation
  • Ovarian cancer
  • Tumor microenvironment

Fingerprint

Dive into the research topics of 'Cancer Associated Fibroblasts express pro-inflammatory factors in human breast and ovarian tumors'. Together they form a unique fingerprint.

Cite this