Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

Neta Erez, Morgan Truitt, Peter Olson, Douglas Hanahan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Cancer-associated fibroblasts (CAFs) support tumorigenesis by stimulating angiogenesis, cancer cell proliferation, and invasion. We demonstrate that CAFs also mediate tumor-enhancing inflammation. Using a mouse model of squamous skin carcinogenesis, we found a proinflammatory gene signature in CAFs isolated from dysplastic skin. This signature was maintained in CAFs from subsequent skin carcinomas and was evident in mammary and pancreatic tumors in mice and in cognate human cancers. The inflammatory signature was already activated in CAFs isolated from the initial hyperplastic stage in multistep skin tumorigenesis. CAFs from this pathway promoted macrophage recruitment, neovascularization, and tumor growth, activities that are abolished when NF-κB signaling was inhibited. Additionally, we show that normal dermal fibroblasts can be "educated" by carcinoma cells to express proinflammatory genes.

Original languageEnglish
Pages (from-to)135-147
Number of pages13
JournalCancer Cell
Volume17
Issue number2
DOIs
StatePublished - 17 Feb 2010
Externally publishedYes

Keywords

  • CELLCYCLE
  • CELLIMMUNO
  • SIGNALING

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