TY - JOUR
T1 - Canalization of tomato fruit metabolism
AU - Alseekh, Saleh
AU - Tong, Hao
AU - Scossa, Federico
AU - Brotman, Yariv
AU - Vigroux, Florian
AU - Tohge, Takayuki
AU - Ofner, Itai
AU - Zamir, Dani
AU - Nikoloski, Zoran
AU - Fernie, Alisdair R.
N1 - Publisher Copyright:
© American Society of Plant Biologists.
PY - 2017/11
Y1 - 2017/11
N2 - To explore the genetic robustness (canalization) of metabolism, we examined the levels of fruit metabolites in multiple harvests of a tomato introgression line (IL) population. The IL partitions the whole genome of the wild species Solanum pennellii in the background of the cultivated tomato (Solanum lycopersicum). We identified several metabolite quantitative trait loci that reduce variability for both primary and secondary metabolites, which we named canalization metabolite quantitative trait loci (cmQTL). We validated nine cmQTL using an independent population of backcross inbred lines, derived from the same parents, which allows increased resolution in mapping the QTL previously identified in the ILs. These cmQTL showed little overlap with QTL for the metabolite levels themselves. Moreover, the intervals they mapped to harbored few metabolism-associated genes, suggesting that the canalization of metabolism is largely controlled by regulatory genes.
AB - To explore the genetic robustness (canalization) of metabolism, we examined the levels of fruit metabolites in multiple harvests of a tomato introgression line (IL) population. The IL partitions the whole genome of the wild species Solanum pennellii in the background of the cultivated tomato (Solanum lycopersicum). We identified several metabolite quantitative trait loci that reduce variability for both primary and secondary metabolites, which we named canalization metabolite quantitative trait loci (cmQTL). We validated nine cmQTL using an independent population of backcross inbred lines, derived from the same parents, which allows increased resolution in mapping the QTL previously identified in the ILs. These cmQTL showed little overlap with QTL for the metabolite levels themselves. Moreover, the intervals they mapped to harbored few metabolism-associated genes, suggesting that the canalization of metabolism is largely controlled by regulatory genes.
UR - http://www.scopus.com/inward/record.url?scp=85037723586&partnerID=8YFLogxK
U2 - 10.1105/tpc.17.00367
DO - 10.1105/tpc.17.00367
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C2 - 29093214
AN - SCOPUS:85037723586
SN - 1040-4651
VL - 29
SP - 2753
EP - 2765
JO - Plant Cell
JF - Plant Cell
IS - 11
ER -