Can We Predict a Higher Risk of Urothelial Bladder Cancer With a Simple Blood Test?

Brendan Wallace*, Snir Dekalo, Mhran Kabha, Ishai Mintz, Haim Matzkin, Nicola J. Mabjeesh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background/Aim: The COVID-19 pandemic highlighted the need to develop tools prioritizing high risk patients for urgent evaluation. Our objective was to determine whether Glasgow Prognostic Score (GPS), an inflammation-based score, can predict higher grade and stage urothelial bladder cancer in patients with gross hematuria who need urgent evaluation. Patients and Methods: We analyzed a database of 129 consecutive patients presenting with gross hematuria. GPS was calculated using pretreatment C-reactive protein (CRP) and albumin levels. Patients with bacteriuria or other known malignancies were excluded. The relationship between GPS and final diagnosis was analyzed with multivariate logistic regression. Results: A total of 101 patients were included in the study and 24 patients were identified without any pathology and 77 with a bladder tumor. Pathology demonstrated 21 with muscle invasive, 18 with high grade non-muscle invasive, and 38 with low grade superficial bladder cancer. Twenty-six of 39 (67%) patients with high grade tumors had a GPS of 1 or 2 compared to only 8 out of 62 (13%) patients with either low grade or negative findings (p<0.0001). Ten of 21 (48%) patients with muscle invasive disease had a GPS of 2 compared to 1 out of 18 (6%) with high grade non muscle invasive tumors (p=0.04). On multivariate analysis, GPS was a strong independent predictor of high grade and stage bladder cancer. Conclusion: GPS may serve as a highly accessible predictor of high grade, high stage, and large urothelial bladder tumors at the time of initial evaluation and can help identify patients who need urgent evaluation.

Original languageEnglish
Pages (from-to)3569-3573
Number of pages5
JournalAnticancer Research
Issue number7
StatePublished - Jul 2022


  • C-reactive protein
  • Glasgow prognostic score
  • albumin
  • urothelial bladder cancer


Dive into the research topics of 'Can We Predict a Higher Risk of Urothelial Bladder Cancer With a Simple Blood Test?'. Together they form a unique fingerprint.

Cite this