Can growth hormone increase, after clonidine administration, predict the dose of human menopausal hormone needed for induction of ovulation?

Y. Menashe, B. Lunenfeld, C. Pariente, Y. Frenkel, S. Mashiach

Research output: Contribution to journalArticlepeer-review

Abstract

Recent observations claimed that growth hormone (GH) administration increased the sensitivity of the ovary to gonadotropin stimulation. These findings prompted us to assess whether ovarian response to human menopausal gonadotropin (hMG) is correlated to GH reserve. Before hMG administration, 25 patients were tested for GH reserve by administration of clonidine. Of the 25 patients, 8 showed a significant increase in GH (9.2 ± 4.5 ng/mL) and needed a significantly lower dose of hMG/human chorionic gonadotropin to elicit a good ovarian response than the 17 patients who did not respond to clonidine by GH increase (2.04 ± 1.2 ng/mL). Our results demonstrate that GH response to clonidine administration may help to estimate the initial dose range of hMB necessary for induction of ovulation.

Original languageEnglish
Pages (from-to)432-435
Number of pages4
JournalFertility and Sterility
Volume53
Issue number3
DOIs
StatePublished - 1990
Externally publishedYes

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