Calorimetric studies on the interaction of gangliosides with phospholipids and myelin basic protein

Ben Ami Sela*, Diana Bach

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Differential scanning calorimetry was employed to investigate the interaction of GM1 gangliosides with phospholipids (phosphatidylethanolamine, phosphatidylserine or phosphatidylcholine). It was found that GM1 is completely miscible with phosphatidylethanolamine; however, the interaction with phosphatidylserine is minimal. Addition of excess Ca2+ to the interaction products of GM1 with phosphatidylcholine or phosphatidylethanolamine did not induce phase separation. The influence of myelin basic protein on the thermotropic behaviour of GM1 was also studied. It was found that basic protein has a very strong perturbing effect on GM1 micelles.

Original languageEnglish
Pages (from-to)177-182
Number of pages6
JournalBBA - Biomembranes
Volume771
Issue number2
DOIs
StatePublished - 11 Apr 1984
Externally publishedYes

Funding

FundersFunder number
Associazione Italiana Sclerosi Multipla

    Keywords

    • (Bovine brain)
    • Differential scanning calorimetry
    • Ganglioside - phospholipid interaction
    • Myelin basic protein

    Fingerprint

    Dive into the research topics of 'Calorimetric studies on the interaction of gangliosides with phospholipids and myelin basic protein'. Together they form a unique fingerprint.

    Cite this