Calcium-independent activation of hypothalamic type I protein kinase C by unsaturated fatty acids

Zvi Naor*, Mark S. Shearman, Akira Kishimoto, Yasutomi Nishizuka

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Among multiple subspecies of the protein kinase C (PKC) family, type I PKC from the hypothalamus, having the structure related to the γ-sequence, responds to low concentrations of arachidonic acid to exhibit marked enzymatic activity. This mode of activation does not require elevated Ca2+ levels, nor does it depend on diacylglycerol and phospholipid. Type I PKC is expressed only in limited regions of central nervous tissues, such as the hypothalamus. This PKC subspecies is not detected in the pituitary gland. The results suggest that the activation of type I PKC may not always be directly associated with inositol phospholipid hydrolysis, and that this subspecies may play a role in the modulation of specialized functions of the hypothalamus.

Original languageEnglish
Pages (from-to)1043-1048
Number of pages6
JournalMolecular Endocrinology
Volume2
Issue number11
DOIs
StatePublished - Nov 1988
Externally publishedYes

Fingerprint

Dive into the research topics of 'Calcium-independent activation of hypothalamic type I protein kinase C by unsaturated fatty acids'. Together they form a unique fingerprint.

Cite this