Calcium homeostasis, bone metabolism and safety aspects during long-term treatment with a GnRH agonist

N. Eckstein, J. Foldes, Y. Feinstein, I. Vagman, A. Eshel, R. Steinberg, M. Statter, R. Limor, D. Ayalon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Thirty-five women with symptomatic fibroids were treated with monthly injections of 3.2 mg microcapsulated D-Trp-6-LHRH for 6 months. During treatment serum 17β-oestradiol levels decreased, falling to castration levels associated with a reduction in the volume of the fibroids. In 16 patients a complete calcium homeostasis and bone metabolism work-up was carried out during treatment and subsequently for a 6-month follow-up period. Bone mineral content (BMC) and Compton bone densitometry readings remained unchanged. There were significant increases in serum calcium phosphate and alkaline phosphatase concentrations. A slight although not significant increase was observed in osteocalcin and parathyroid hormone (PTH) serum levels. Serum 1,25(OH)2D3 values decreased significantly after 3 months of treatment. Urinary hydroxyproline/creatinine and calcium/creatinine ratios as well as 24-h urinary calcium values increased significantly during the treatment period but decreased rapidly to pretreatment values after 3 months in the follow-up period. The endocrine changes induced by the GnRH-agonist treatment were associated with reversible biochemical signs of increased bone turnover and no significant changes in bone mass, suggesting that the treatment can be administered safely for a period of 6 months in patients with oestrogen-dependent diseases.

Original languageEnglish
Pages (from-to)25-32
Number of pages8
Issue number1
StatePublished - Aug 1992
Externally publishedYes


  • GnRH-analogue treatment
  • bone metabolism
  • calcium homeostasis
  • safety aspects


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