@article{0a55bf81e7c341018283c260ed9564df,
title = "Calcium-dependent protein phosphorylation and dephosphorylation in intact brain neurons in culture",
abstract = "Preincubation of intact fetal rat brain neurons in culture with 32Pi results in the incorporation of 32Pi into about 20 specific proteins. Upon stimulation by electrical field stimulation or by K+-induced depolarization, highly significant calcium-dependent increase in phosphorylation of a protein of app. Mr 43 000 and decrease in phosphorylation of an app. Mr 55 000 protein occur. These changes can be attributed to the entry of Ca2+ into the cellular cytoplasm since they can occur upon selective permeabilization of the cell membrane to Ca2+ by the Ca2+-ionophore A23187 and are not observed upon stimulation of the cells in the presence of the Ca2+ channel blocker D-600. These data suggest that these phosphoproteins may be involved in the regulation of processes underlying neurotransmitter release.",
keywords = "Phosphorylation Brain Neuron Neurotransmitter release",
author = "Neomi Zurgil and Nava Zisapel",
note = "Funding Information: ACKNOWLEDGEMENT This researchw ass upportedin part by the Israel Centerf or Psychobiology,C harlesE . Smith Family Foundation (grant no.015-9540).",
year = "1983",
month = jun,
day = "13",
doi = "10.1016/0014-5793(83)80508-0",
language = "אנגלית",
volume = "156",
pages = "257--261",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "John Wiley and Sons Inc.",
number = "2",
}