CAG repeat polymorphism within the KCNN3 gene is a significant contributor to susceptibility to anorexia nervosa: A case-control study of female patients and several ethnic groups in the Israeli Jewish population

Maya Koronyo-Hamaoui, Eva Gak, Daniel Stein, Amos Frisch, Yardena Danziger, Shani Leor, Elena Michaelovsky, Neil Laufer, Cynthia Carel, Silvana Fennig, Marc Mimouni, Alan Apter, Boleslav Goldman, Gad Barkai, Abraham Weizman

Research output: Contribution to journalArticlepeer-review

Abstract

The human small-conductance Ca2+-activated potassium channel gene KCNN3 has been involved in mechanisms underlying neuronal function and plasticity. A multiallelic CAG repeat polymorphism within the KCNN3 has been associated with schizophrenia and bipolar disorder. We have previously reported in a family-based study that longer CAG repeats are preferentially transmitted to patients with anorexia nervosa (AN). The present study extends the analysis of KCNN3 allele distribution to a larger series of AN female patients and control groups, incorporating information on ethnicity and co-morbidities associated with AN. The data analysis is presented while considering separately the two alleles of each individual, namely a minor (shorter) and a major (longer) allele. This study has found that the KCNN3 allele distribution in the general Israeli population does not differ significantly in at least four Jewish ethnic groups of Ashkenazi, North African, Iraqi, and Yemenite origin. These have been used as control groups in a matched case-control analysis that has demonstrated a significant over-representation of KCNN3 alleles with longer CAG repeats among AN patients (P < 0.001 for the major allele and P = 0.035 for allele sum). Under dichotomization, a significantly higher prevalence of the L allele (>19 repeats) has been observed among AN patients (P < 0.001). While considering AN and co-morbid phenotypes, a tendency towards longer (L) alleles has been observed in the subset of patients with obsessive-compulsive disorder (OCD) co-morbidity. These findings further implicate KCNN3 as a significant contributor to predisposition to AN.

Original languageEnglish
Pages (from-to)76-80
Number of pages5
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume131 B
Issue number1
DOIs
StatePublished - 15 Nov 2004

Keywords

  • Anorexia nervosa
  • CAG repeat polymorphism
  • Co-morbidity
  • Ethnicity
  • KCNN3 (SK3, hSKCa3)

Fingerprint

Dive into the research topics of 'CAG repeat polymorphism within the KCNN3 gene is a significant contributor to susceptibility to anorexia nervosa: A case-control study of female patients and several ethnic groups in the Israeli Jewish population'. Together they form a unique fingerprint.

Cite this