C-reactive protein in dogs.

D. Caspi*, F. W. Snel, R. M. Batt, D. Bennett, G. R. Rutteman, E. G. Hartman, M. L. Baltz, E. Gruys, M. B. Pepys

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Serum concentrations of C-reactive protein (CRP) in dogs with various diseases or undergoing various procedures were measured by specific immunoassay. In 20 healthy dogs from various sources, values were all less than 5 mg/L, but in 22 healthy dogs from a single source, values ranged from less than 5 mg/L in 14 dogs and from 8 to 67 mg/L in 8 dogs. Increased concentrations of serum CRP were attained 24 hours after injection of casein (n = 9; median 188 mg/L), ovariohysterectomy (n = 11; median, 144 mg/L), or elective, nonacute orthopedic surgery (n = 10; median, 83 mg/L). After inoculation of Leptospira interrogans serovar canicola (n = 5), the behavior of serum CRP as an acute-phase reactant provided a sensitive and precise objective reflection of in vivo response. The CRP concentration in random single-serum samples from 73 dogs with other inflammatory and noninflammatory disorders ranged from normal (less than 5 mg/L) to 246 mg/L and generally correlated with the extent and activity of disease.

Original languageEnglish
Pages (from-to)919-921
Number of pages3
JournalAmerican Journal of Veterinary Research
Issue number6
StatePublished - Jun 1987


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