Abstract
Interference is said to take place whenever crossover events fail to occur at random along the chromosome. The nature of higher order interference (positive or negative) is introduced. It is shown how interference is determined by the chiasma formation process operating along the chromosome and especially by the count-location (C-L) chiasma formation process. We discuss a simple mechanism among C-L processes that can generate prescribed higher order positive interference or prescribed higher order negative interference between any two collections of disjoint genomic regions.
Original language | English |
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Pages (from-to) | 773-788 |
Number of pages | 16 |
Journal | Journal of Mathematical Biology |
Volume | 34 |
Issue number | 7 |
DOIs | |
State | Published - 1996 |
Keywords
- Count-location (C-L) process
- Higher-order interference -linkage values
- Map function
- Recombination