C-L processes involving higher order positive (negative) interference for any two collections of disjoint chromosomal regions

U. Liberman*, H. Manos

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Interference is said to take place whenever crossover events fail to occur at random along the chromosome. The nature of higher order interference (positive or negative) is introduced. It is shown how interference is determined by the chiasma formation process operating along the chromosome and especially by the count-location (C-L) chiasma formation process. We discuss a simple mechanism among C-L processes that can generate prescribed higher order positive interference or prescribed higher order negative interference between any two collections of disjoint genomic regions.

Original languageEnglish
Pages (from-to)773-788
Number of pages16
JournalJournal of Mathematical Biology
Volume34
Issue number7
DOIs
StatePublished - 1996

Keywords

  • Count-location (C-L) process
  • Higher-order interference -linkage values
  • Map function
  • Recombination

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