Burden of heart failure and underlying causes in 195 countries and territories from 1990 to 2017

Nicola Luigi Bragazzi, Wen Zhong, Jingxian Shu, Arsalan Abu Much, Dor Lotan, Avishay Grupper, Arwa Younis, Haijiang Dai*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

283 Scopus citations


Aims: To provide the first systematic analysis of the burden and underlying causes of heart failure (HF) in 195 countries and territories from 1990 to 2017. Methods and results: We collected detailed information on prevalence, years lived with disability (YLDs), and underlying causes of HF from the Global Burden of Disease study 2017. Numbers and age-standardized rates of HF prevalence and YLDs were compared by age, sex, socio-demographic index (SDI), and location. The proportions of HF age-standardized prevalence rates due to 23 underlying causes were also presented. Globally, the age-standardized prevalence and YLD rates of HF in 2017 were 831.0 and 128.2 per 100 000 people, a decrease of-7.2% and-0.9% from 1990, respectively. Nevertheless, the absolute numbers of HF prevalent cases and YLDs have increased by 91.9% and 106.0% from 1990, respectively. There is significant geographic and socio-demographic variation in the levels and trends of HF burden from 1990 to 2017. Among all causes of HF, ischaemic heart disease accounted for the highest proportion (26.5%) of age-standardized prevalence rate of HF in 2017, followed by hypertensive heart disease (26.2%), chronic obstructive pulmonary disease (23.4%). Conclusion: HF remains a serious public health problem worldwide, with increasing age-standardized prevalence and YLD rates in countries with relatively low SDI. More geo-specific strategies aimed at preventing underlying causes and improving medical care for HF are warranted to reduce the future burden of this condition.

Original languageEnglish
Pages (from-to)1682-1690
Number of pages9
JournalEuropean Journal of Preventive Cardiology
Issue number15
StatePublished - 1 Dec 2021


FundersFunder number
Hospital Pharmacy Research Fund of Guangdong2019YX18
Bill and Melinda Gates Foundation
National Natural Science Foundation of China81974090


    • Cause
    • Global
    • Heart failure
    • Prevalence
    • Year lived with disability


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