Bullous Dermatoses, Infectious Agents, and Vaccines

Yaron Zafrir, Nancy Agmon-Levin, Sharon Baum

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


An autoimmune bullous disorder encompasses a heterogeneous group of disorders characterized by the presence of blisters and autoantibodies against structural components of the skin: desmosomal proteins, adhesion molecules of the dermal-epidermal junction, and epidermal/tissue transglutaminase. The most common autoimmune bullous diseases are bullous pemphigoid (BP) and pemphigus vulgaris (PV). Diagnosis of autoimmune bullous disorders relies upon a combination of the clinical picture and the detection of autoantibodies in the skin and/or serum of the patient. BP appears to have no gender preference and no ethnic or racial predilection with no difference in incidence between the genders. The mean age of PV onset is between 40 and 60 years, and it usually affects both genders equally. The etiology of both BP and PV is poorly understood, but as in other autoimmune diseases it has been shown to be associated with various environmental factors, including emotional and/or physical stress, infections, and vaccinations.

Original languageEnglish
Title of host publicationVaccines and Autoimmunity
Number of pages8
ISBN (Electronic)9781118663721
ISBN (Print)9781118663431
StatePublished - 1 Jan 2014


  • Bullous dermatoses disorders
  • Bullous pemphigoid (BP)
  • Immunohistochemistry
  • Influenza vaccine
  • Pemphigus vulgaris (PV)


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