TY - JOUR
T1 - Budding transition of asymmetric two-component lipid domains
AU - Wolff, Jean
AU - Komura, Shigeyuki
AU - Andelman, David
N1 - Publisher Copyright:
© 2016 American Physical Society.
PY - 2016/9/14
Y1 - 2016/9/14
N2 - We propose a model that accounts for the budding transition of asymmetric two-component lipid domains, where the two monolayers (leaflets) have different average compositions controlled by independent chemical potentials. Assuming a coupling between the local curvature and local lipid composition in each of the leaflets, we discuss the morphology and thermodynamic behavior of asymmetric lipid domains. The membrane free-energy contains three contributions: the bending energy, the line tension, and a Landau free-energy for a lateral phase separation. Within a mean-field treatment, we obtain various phase diagrams containing fully budded, dimpled, and flat states as a function of the two leaflet compositions. The global phase behavior is analyzed, and depending on system parameters, the phase diagrams include one-phase, two-phase, and three-phase regions. In particular, we predict various phase coexistence regions between different morphologies of domains, which may be observed in multicomponent membranes or vesicles.
AB - We propose a model that accounts for the budding transition of asymmetric two-component lipid domains, where the two monolayers (leaflets) have different average compositions controlled by independent chemical potentials. Assuming a coupling between the local curvature and local lipid composition in each of the leaflets, we discuss the morphology and thermodynamic behavior of asymmetric lipid domains. The membrane free-energy contains three contributions: the bending energy, the line tension, and a Landau free-energy for a lateral phase separation. Within a mean-field treatment, we obtain various phase diagrams containing fully budded, dimpled, and flat states as a function of the two leaflet compositions. The global phase behavior is analyzed, and depending on system parameters, the phase diagrams include one-phase, two-phase, and three-phase regions. In particular, we predict various phase coexistence regions between different morphologies of domains, which may be observed in multicomponent membranes or vesicles.
UR - http://www.scopus.com/inward/record.url?scp=84990195483&partnerID=8YFLogxK
U2 - 10.1103/PhysRevE.94.032406
DO - 10.1103/PhysRevE.94.032406
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 27739709
AN - SCOPUS:84990195483
VL - 94
JO - Physical Review E
JF - Physical Review E
SN - 2470-0045
IS - 3
M1 - 032406
ER -