Brugada syndrome: Cellular mechanisms and approaches to therapy

Charles Antzelevitch*, Sami Viskin

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations


Nearly 15 years have passed since Pedro and Josep Brugada introduced the syndrome of ST-segment elevation and right bundle branch block (RBBB) associated with a high incidence of ventricular tachycardia/ventricular fibrillation (VT/VF) as a new clinical entity.1 Over 16 years have transpired since the introduction of the concept of phase 2 reentry (induced by sodium channel block), the mechanism believed to underlie the development of arrhythmogenesis in this clinical syndrome.2,3 Thus, the entity, which in 1996 came to be known as the Brugada syndrome,4,5 evolved in the experimental laboratory and in the clinic along parallel but separate tracks until the late 1990s.6

Original languageEnglish
Title of host publicationElectrical Diseases of the Heart
Subtitle of host publicationGenetics, Mechanisms, Treatment, Prevention
PublisherSpringer London
Number of pages36
ISBN (Print)9781846288531
StatePublished - 2008
Externally publishedYes


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