Brief electrical stimulation of c-fibers in rats produces thermal hyperalgesia lasting weeks

Jean Jacques Vatine, Ron Argov, Ze'ev Seltzer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Nerve injury produces neuropathic pain in some humans, but the nature of the signal triggering the pain is still unknown. When injured, many afferent fibers emit a prolonged discharge of action potentials. This input triggers pain disorders in rats following some, but not other types of total and partial nerve injury. In the present study we report that similar sensory disorders develop in rats by electrically stimulating an intact sciatic nerve. Robust thermal hyperalgesia and weak mechanical allodynia developed rapidly, lasting 3-5 weeks thereafter, but only when activating C-fibers. Thus, a discharge mimicking injury discharge in C-fibers, in the absence of any intended damage to the stimulated nerve, is sufficient to alter chronically central processing of sensory input.

Original languageEnglish
Pages (from-to)125-128
Number of pages4
JournalNeuroscience Letters
Volume246
Issue number3
DOIs
StatePublished - 10 Apr 1998
Externally publishedYes

Funding

FundersFunder number
Fritz Thyssen Stiftung
United States-Israel Binational Science Foundation
Hebrew University of Jerusalem

    Keywords

    • Allodynia
    • Hyperalgesia
    • Injury discharge
    • Neuropathic pain
    • Peripheral nerve stimulation
    • Rat

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