Breast enlargement induced by D-penicillamine

Joseph Z. Tchebiner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: To report a patient with reversible breast enlargement due to D-penicillamine treatment for scleroderma. CASE SUMMARY: A 55-year-old white woman developed enlarged breasts during D-penicillamine therapy for scleroderma. The enlargement regressed following discontinuation of the drug, and planned breast reduction surgery was avoided. DISCUSSION: D-Penicillamine has been used in the treatment of various diseases including scleroderma. Breast enlargement has been previously described as a rare adverse effect of this drug. The enlargement subsided following discontinuation of the medication. CONCLUSIONS: Attention is called to this rare adverse effect in an effort to avoid unnecessary diagnostic or therapeutic procedures, including surgery.

Original languageEnglish
Pages (from-to)444-445
Number of pages2
JournalAnnals of Pharmacotherapy
Issue number3
StatePublished - 2002
Externally publishedYes


  • Breast enlargement
  • D-penicillamine
  • Scleroderma


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