OBJECTIVE: To report a patient with reversible breast enlargement due to D-penicillamine treatment for scleroderma. CASE SUMMARY: A 55-year-old white woman developed enlarged breasts during D-penicillamine therapy for scleroderma. The enlargement regressed following discontinuation of the drug, and planned breast reduction surgery was avoided. DISCUSSION: D-Penicillamine has been used in the treatment of various diseases including scleroderma. Breast enlargement has been previously described as a rare adverse effect of this drug. The enlargement subsided following discontinuation of the medication. CONCLUSIONS: Attention is called to this rare adverse effect in an effort to avoid unnecessary diagnostic or therapeutic procedures, including surgery.
- Breast enlargement