TY - CHAP
T1 - Breast Cancer Progression: A “Vicious Cycle” of Pro-Malignancy Activities is Mediated by Inflammatory Cells, Chemokines and Cytokines
AU - Ben-Baruch, A.
PY - 2005
Y1 - 2005
N2 - Breast cancer progression is a multi-step process, affected by intrinsic, as well as by microenvironmental factors. The inflammatory milieu of breast tumors, comprising of cells, chemokines and cytokines, was recently suggested to have a major role in this process. The current chapter addresses the presence of these elements in breast tumors, and their roles in the malignancy and metastatic fate of breast cancer. First, the presence of Tumor-Associated Macrophages (TAM), and the array of tumor-promoting activities that they exert in breast tumors, is described. Thereafter, the inflammatory chemokines CCL2 (MCP-1), CCL5 (RANTES) and CXCL8 (Interleukin 8) are addressed, followed by description of the expression and roles of inflammatory cytokines, which are monocyte/macrophage-derived, namely Interleukin 1 (IL-1), Tumor Necrosis Factor α (TNFα) and Interleukin 6 (IL-6). Throughout the chapter, major emphasis is put on the manner by which the different inflammatory mediators cross-interact with each other, as well as with the tumor cells, together establishing an inflammatory microenvironment that consists of an extensive network of pro-malignancy activities.
AB - Breast cancer progression is a multi-step process, affected by intrinsic, as well as by microenvironmental factors. The inflammatory milieu of breast tumors, comprising of cells, chemokines and cytokines, was recently suggested to have a major role in this process. The current chapter addresses the presence of these elements in breast tumors, and their roles in the malignancy and metastatic fate of breast cancer. First, the presence of Tumor-Associated Macrophages (TAM), and the array of tumor-promoting activities that they exert in breast tumors, is described. Thereafter, the inflammatory chemokines CCL2 (MCP-1), CCL5 (RANTES) and CXCL8 (Interleukin 8) are addressed, followed by description of the expression and roles of inflammatory cytokines, which are monocyte/macrophage-derived, namely Interleukin 1 (IL-1), Tumor Necrosis Factor α (TNFα) and Interleukin 6 (IL-6). Throughout the chapter, major emphasis is put on the manner by which the different inflammatory mediators cross-interact with each other, as well as with the tumor cells, together establishing an inflammatory microenvironment that consists of an extensive network of pro-malignancy activities.
U2 - 10.1007/1-4020-3414-8_11
DO - 10.1007/1-4020-3414-8_11
M3 - Chapter
SN - 978-1-4020-3413-8
T3 - Cancer Growth and Progression
SP - 189
EP - 217
BT - Integration/Interaction of Oncologic Growth
A2 - Meadows, Gary G.
PB - Springer Netherlands
CY - Dordrecht
ER -