Breast cancer in the elderly: Histological, hormonal and surgical characteristics

I. Pappo*, T. Karni, J. Sandbank, I. Dinur, A. Sella, V. Stahl-Kent, I. Wasserman, A. Halevy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The characteristics, menstrual risk factors and surgical therapy of 187 consecutive patients more than 70 years of age (mean: 75.9) were investigated and compared with those of 609 patients less than 70 years of age (mean: 53.9). There was no difference in stage, size, state of axillary nodes, grade, histological types, Ki-67, vascular invasion, estrogen receptor rate, and HER-2/neu (+) rate. Positive progesterone receptor rate was higher in older patients (54.7% vs. 63.1%). Tumors were larger (p = 0.01) and their stage higher (p = 0.014) in patients more than 80 years of age. All menstrual risk factors were similar in the two groups. Positive familial history was more frequent in patients <60 years. Significantly more young patients used hormone replacement therapy (HRT) (21.8 vs. 8.6%). Older patients underwent less breast-conserving surgery (36.1 vs. 55.1%), and less axillary lymph node dissection (ALND) (69.7 vs. 84.9%). We conclude that breast cancer characteristics and menstrual risk factors are similar in the two age groups.

Original languageEnglish
Pages (from-to)60-67
Number of pages8
Issue number1
StatePublished - Feb 2007
Externally publishedYes


  • Breast cancer
  • Elderly patients
  • Hormonal risk factors
  • Mastectomy


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