Breakthrough cerebral toxoplasmosis in a patient receiving atovaquone prophylaxis after a hematopoietic stem cell transplantation

Orli Megged, Itamar Shalit, Isaac Yaniv, Jerry Stein, Salvador Fisher, Itzhak Levy

Research output: Contribution to journalArticlepeer-review

Abstract

We describe a case of breakthrough cerebral toxoplasmosis during atovaquone therapy in a child who was intolerant of conventional prophylactic regimens after hematopoietic stem cell transplantation. The available data on the efficacy of atovaquone prophylaxis in Toxoplasma sero-positive stem cell transplant recipients remain limited, and other strategies, such as preemptive strategy using toxoplasma PCR or TMP-SMX desensitization should be considered in this setting.

Original languageEnglish
Pages (from-to)902-905
Number of pages4
JournalPediatric Transplantation
Volume12
Issue number8
DOIs
StatePublished - Dec 2008

Keywords

  • Atovaquone
  • Encephalitis
  • HSCT
  • Toxoplasmosis

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