TY - JOUR
T1 - Breakthrough candida infection in a preterm infant with congenital cutaneous Candida albicans infection
AU - Adler, Amos
AU - Litmanovitz, Ita
AU - Regev, Rivka
AU - Arnon, Shmuel
AU - Bauer, Sophia
AU - Dolfin, Tzipora
PY - 2005/4
Y1 - 2005/4
N2 - Amphotericin B is the primary antifungal agent used for candida sepsis in neonates. Breakthrough candidemia was not reported in neonates during either amphotericin B or liposomal amphotericin B (AmBisome) treatment. We describe a case of a premature infant with congenital cutaneous candida infection, who had two episodes of breakthrough infection, from Candida albicans and Candida parapsilosis, while he was treated with amphotericin B and AmBisome, respectively. We discuss the pathogenesis of breakthrough infections, and the relevance of antifungal resistance and sensitivities testing.
AB - Amphotericin B is the primary antifungal agent used for candida sepsis in neonates. Breakthrough candidemia was not reported in neonates during either amphotericin B or liposomal amphotericin B (AmBisome) treatment. We describe a case of a premature infant with congenital cutaneous candida infection, who had two episodes of breakthrough infection, from Candida albicans and Candida parapsilosis, while he was treated with amphotericin B and AmBisome, respectively. We discuss the pathogenesis of breakthrough infections, and the relevance of antifungal resistance and sensitivities testing.
KW - Amphotericin B
KW - Antifungal susceptibilities testing
KW - Congenital cutaneous candidiasis
KW - Fluconazole
UR - http://www.scopus.com/inward/record.url?scp=17844398965&partnerID=8YFLogxK
U2 - 10.1055/s-2005-864855
DO - 10.1055/s-2005-864855
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 15838753
AN - SCOPUS:17844398965
SN - 0735-1631
VL - 22
SP - 169
EP - 172
JO - American Journal of Perinatology
JF - American Journal of Perinatology
IS - 3
ER -