TY - JOUR
T1 - Brain Localizing Activity of Hetero- and Isoimmune Sera Directed against Lymphocytic Cells
AU - Witz, I.
AU - Yagi, Y.
AU - Pressman, D.
N1 - Funding Information:
Supported in part by Contract No. AT-(30-1)-2651 from the U.S. Atomic Energy Commission. 1
PY - 1969/3
Y1 - 1969/3
N2 - Isoantibodies prepared in C57BL/6 mice against lymphocytic leukemia cells of DBA/2 mice (L1210) exhibited in vivo localization in the brain of DBA/2 mice. Rabbit antisera prepared against the same cells exhibited a lower localization in DBA/2 brain, while rabbit antibodies prepared against normal lymphoid organs of DBA/2 mice exhibited a much lower localization. The localization of both the isoantibodies and the heteroantibodies was very rapid. Maximal amounts of antibodies were fixed to the brain 2 hr after i.v. injection.
AB - Isoantibodies prepared in C57BL/6 mice against lymphocytic leukemia cells of DBA/2 mice (L1210) exhibited in vivo localization in the brain of DBA/2 mice. Rabbit antisera prepared against the same cells exhibited a lower localization in DBA/2 brain, while rabbit antibodies prepared against normal lymphoid organs of DBA/2 mice exhibited a much lower localization. The localization of both the isoantibodies and the heteroantibodies was very rapid. Maximal amounts of antibodies were fixed to the brain 2 hr after i.v. injection.
UR - http://www.scopus.com/inward/record.url?scp=0014483277&partnerID=8YFLogxK
U2 - 10.3181/00379727-130-33689
DO - 10.3181/00379727-130-33689
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AN - SCOPUS:0014483277
SN - 0037-9727
VL - 130
SP - 928
EP - 930
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
IS - 3
ER -
