Isoantibodies prepared in C57BL/6 mice against lymphocytic leukemia cells of DBA/2 mice (L1210) exhibited in vivo localization in the brain of DBA/2 mice. Rabbit antisera prepared against the same cells exhibited a lower localization in DBA/2 brain, while rabbit antibodies prepared against normal lymphoid organs of DBA/2 mice exhibited a much lower localization. The localization of both the isoantibodies and the heteroantibodies was very rapid. Maximal amounts of antibodies were fixed to the brain 2 hr after i.v. injection.
|United States Atomic Energy Commission