Brain Localizing Activity of Hetero- and Isoimmune Sera Directed against Lymphocytic Cells

I. Witz, Y. Yagi, D. Pressman

Research output: Contribution to journalArticlepeer-review

Abstract

Isoantibodies prepared in C57BL/6 mice against lymphocytic leukemia cells of DBA/2 mice (L1210) exhibited in vivo localization in the brain of DBA/2 mice. Rabbit antisera prepared against the same cells exhibited a lower localization in DBA/2 brain, while rabbit antibodies prepared against normal lymphoid organs of DBA/2 mice exhibited a much lower localization. The localization of both the isoantibodies and the heteroantibodies was very rapid. Maximal amounts of antibodies were fixed to the brain 2 hr after i.v. injection.

Original languageEnglish
Pages (from-to)928-930
Number of pages3
JournalExperimental Biology and Medicine
Volume130
Issue number3
DOIs
StatePublished - Mar 1969
Externally publishedYes

Funding

FundersFunder number
United States Atomic Energy Commission

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