Brain injury-dependent expression of activity-dependent neuroprotective protein

Roy Zaltzman, Alexander Alexandrovich, Sara M. Beni, Victoria Trembovler, Esther Shohami, Illana Gozes

Research output: Contribution to journalArticlepeer-review

Abstract

Activity-dependent neuroprotective protein (ADNP), a crucial brain development factor, contains a unique sequence, termed NAPVSIPQ, which protects mice against closed head injury (CHI). The aim of this study was to determine whether CHI affects ADNP mRNA expression in the injured brain hemisphere. Male C57JBL/6J mice were subjected to CHI. Brains were removed 5 h, 24 h, 7 d, and 29 d post-CHI. A comparison was made between ADNP mRNA in the injured versus the noninjured hemisphere using real-time polymerase chain reaction. A nonsignificant change (p > 0.05) was found 5 h, 24 h, and 7 d post-CHI. However, a significant increase (p < 0.05) in ADNP mRNA expression was detected in the injured cerebral hemisphere 29 d post-CHI. The data presented may be associated with ADNP's crucial involvement in brain development and response to injury.

Original languageEnglish
Pages (from-to)181-187
Number of pages7
JournalJournal of Molecular Neuroscience
Volume24
Issue number2
DOIs
StatePublished - Sep 2004

Keywords

  • Activity-dependent neuroprotective protein (ADNP)
  • Gene expression
  • Head trauma
  • Real-time polymerase chain reaction (PCR)

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