Brain functional networks reorganization for maintaining gait abilities in aging

Amgad Droby*, Inbal Maidan, Anat Mirelman

*Corresponding author for this work

Research output: Contribution to journalEditorial


Neural changes occurring at the molecular and functional levels in the brain as a function of age were reported by numerous studies. These age-related alterations manifest as local structural and metabolic changes and large-scale functional re-organization of neural circuits, and are accompanied by a decline in multiple cognitive and motor skills [1, 2]. However, the aging process is heterogeneous, varying extensively between individuals. A potential explanation for this variance relates to the concepts of brain reserve, cognitive reserve, and their contribution to brain resilience. Brain resilience is a broad term increasingly used to refer to [one’s] capacity to withstand and maintain functions in the face of aging or disease. Brain reserve (BR) is proposed to be one aspect of brain resilience, offering a quantifiable measure of the neurobiological characteristics of the underlying neural tissue (i.e., neuronal density, tissue volumes, etc.),

Original languageEnglish
Pages (from-to)1230-1231
Number of pages2
Issue number5
StatePublished - 2023


  • aging
  • brain reserve
  • brain resilience
  • functional integration
  • gait


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