Brain and atrial natriuretic peptides in patients with ischemic heart disease with and without heart failure

Michael Arad, Ella Elazar, Avraham Shotan, Rodica Klein, Babeth Rabinowitz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

The objective of the study was the evaluation of natriuretic peptides in ischemic heart disease. Atrial and brain peptides (ANP, BNP) were elevated in patients with ischemicheart failureas compared with patients withanginawithout overt failure, and controls (p< 0.01). BNP/ANP ratio was higher in NYHA class IV than in class III patients (2.67 ± 0.87 vs. 1.52 ± 0.59, respectively). Patients in the angina group, in whom elevated BNP or ANP was found, had subclinical systolic or diastolic dysfunction. There was inverse correlation between BNP, ANP and the left-ventricular ejection fraction (each r = 0.78, p< 0.001). We conclude that BNP is elevated as a result of myocardial dysfunction, but not of ischemia and seems to be a better index of disease stage and prognosis than ANP.

Original languageEnglish
Pages (from-to)12-17
Number of pages6
JournalCardiology
Volume87
Issue number1
DOIs
StatePublished - 1 Jan 1996

Keywords

  • Angina pectoris
  • Atrial
  • Brain
  • Heart failure
  • Natriuretic peptides

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