TY - JOUR
T1 - Bradykinin level in the great cardiac vein during balloon angioplasty of the left anterior descending coronary artery
AU - Eldar, Michael
AU - Hollander, Gerald
AU - Schulhoff, Nancy
AU - Ohlstein, Elliot
AU - Greengart, Alvin
AU - Lichstein, Edgar
AU - Shani, Jacob
PY - 1992/12/15
Y1 - 1992/12/15
N2 - Chest pain is one of the hallmarks of myocardial ischemia (angina pectoris). Exact mechanisms responsible for the production of ischemia-induced pain are not clear.1 A prevailing hypothesis postulates the activation of peripheral nociceptive receptors by substances originating in the ischemic myocardium.2-4 Several investigators have suggested that bradykinin, one of the most potent natural algesic substances, may be responsible for anginal pain.5,6 Kimura et al7 found that coronary ligation in the dog induces a rapid increase in the coronary sinus level of bradykinin. The relation of bradykmin to myocardial ischemic pain in humans has not been previously reported. We studied the plasma bradykinin level in the great cardiac vein during transient myocardial ischemia induced by balloon angioplasty of the left anterior descending coronary artery in humans.
AB - Chest pain is one of the hallmarks of myocardial ischemia (angina pectoris). Exact mechanisms responsible for the production of ischemia-induced pain are not clear.1 A prevailing hypothesis postulates the activation of peripheral nociceptive receptors by substances originating in the ischemic myocardium.2-4 Several investigators have suggested that bradykinin, one of the most potent natural algesic substances, may be responsible for anginal pain.5,6 Kimura et al7 found that coronary ligation in the dog induces a rapid increase in the coronary sinus level of bradykinin. The relation of bradykmin to myocardial ischemic pain in humans has not been previously reported. We studied the plasma bradykinin level in the great cardiac vein during transient myocardial ischemia induced by balloon angioplasty of the left anterior descending coronary artery in humans.
UR - http://www.scopus.com/inward/record.url?scp=0027043216&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(92)90472-B
DO - 10.1016/0002-9149(92)90472-B
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AN - SCOPUS:0027043216
SN - 0002-9149
VL - 70
SP - 1621
EP - 1623
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 20
ER -
