BP fluctuations in the normotensive versus the hypertensive cardiovascular system: Simulation and experiment

S. Akselrod, G. Wasserman, O. Oz, S. Cohen, S. Eliash

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

A computerized model has been designed in order to simulate blood pressure (BP) control and mean BP (MBP) fluctuations in the normal and the hypertensive cardiovascular system. The purpose of this model is to compare between the two systems by allowing their control limbs to function naturally, hoping to obtain the BP fluctuations as experimentally observed in the two strains. In experimental studies performed on normotensive (WKY) vs. spontaneously hypertensive rats (SHR), the authors detected basic differences in the pattern of BP fluctuations. When introducing the respective control parameters of the vagal and beta-sympathetic limbs (experimentally measured) for the two strains of rats, the differences between WKY and SHR cause the low-frequency BP fluctuations to be slightly, but consistently, reduced in SHR. Among other findings, these experiments showed a clearly reduced β-sympathetic gain in SHR as compared to WKY.

Original languageEnglish
Title of host publicationComputers in Cardiology
PublisherPubl by IEEE
Pages701-704
Number of pages4
ISBN (Print)081862485X
StatePublished - 1992
EventProceedings of the 18th Annual Conference on Computers in Cardiology - Venice, Italy
Duration: 23 Sep 199126 Sep 1991

Publication series

NameComputers in Cardiology
ISSN (Print)0276-6574

Conference

ConferenceProceedings of the 18th Annual Conference on Computers in Cardiology
CityVenice, Italy
Period23/09/9126/09/91

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