Botulinum toxin injections for pediatric patients with hereditary spastic paraparesis

Keren Geva-Dayan, Dafna Domenievitz, Rafat Zahalka, Aviva Fattal-Valevski*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Limited information is available on the use of botulinum toxin type A injections for children with hereditary spastic paraplegia. This report includes 12 children with hereditary spastic paraplegia (mean age 4.8 ± 2.5 years) who underwent 1 to 6 sessions of botulinum toxin A injections to the hamstrings, adductors and gastrocnemius muscles. Patients showed both improved muscle tone (mean 1.9 ± 0.5 vs 1.18 ± 0.33, P <.001, Ashworth Scale) and motor function (75.3 ± 11.9 vs 77.7 ± 11, P <.001, Gross Motor Function Measure). The effect lasted for a mean of 6.6 ± 3.6 months. During the study period (mean 2.8 ± 1.8 years), the preinjection Gross Motor Function Measure increased (69.2 ± 14.7 vs 78.3 ± 13.5, P =.005), whereas the Ashworth Scale remained stable, suggesting a prolonged effect of botulinum toxin A on motor function. The authors conclude that botulinum toxin A injections to lower limbs of pediatric patients with hereditary spastic paraplegia result in prolonged functional improvement despite the progressive nature of the disease.

Original languageEnglish
Pages (from-to)969-975
Number of pages7
JournalJournal of Child Neurology
Issue number8
StatePublished - Aug 2010


  • botulinum toxin A
  • hereditary spastic paraparesis
  • lower extremity


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