@article{268299cc015b45b7a0cb17091e940340,
title = "Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice",
abstract = "Deciphering the complex interplay between neuronal activity and mitochondrial function is pivotal in understanding brain aging, a multifaceted process marked by declines in synaptic function and mitochondrial performance. Here, we identified an age-dependent coupling between neuronal and synaptic excitation and mitochondrial DNA transcription (E-TCmito), which operates differently compared to classic excitation-transcription coupling in the nucleus (E-TCnuc). We demonstrated that E-TCmito repurposes molecules traditionally associated with E-TCnuc to regulate mitochondrial DNA expression in areas closely linked to synaptic activation. The effectiveness of E-TCmito weakens with age, contributing to age-related neurological deficits in mice. Boosting brain E-TCmito in aged animals ameliorated these impairments, offering a potential target to counteract age-related cognitive decline.",
author = "Wenwen Li and Jiarui Li and Jing Li and Chen Wei and Tal Laviv and Meiyi Dong and Jingran Lin and Mariah Calubag and Colgan, \{Lesley A.\} and Kai Jin and Bing Zhou and Ying Shen and Haohong Li and Yihui Cui and Zhihua Gao and Tao Li and Hailan Hu and Ryohei Yasuda and Huan Ma",
note = "Publisher Copyright: Copyright {\textcopyright} 2024 the authors, some rights reserved.",
year = "2024",
month = dec,
day = "20",
doi = "10.1126/science.adp6547",
language = "אנגלית",
volume = "386",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6728",
}