TY - JOUR
T1 - Bone strength in multiple sclerosis
T2 - Cortical midtibial speed-of-sound assessment
AU - Achiron, Anat
AU - Edelstein, Shmuel
AU - Ziev-Ner, Y.
AU - Givon, Uri
AU - Rotstein, Zeev
AU - Barak, Yoram
PY - 2004/10
Y1 - 2004/10
N2 - It has been previously suggested that multiple sclerosis (MS) patients are at increased risk for osteoporosis due to reduced mobility, decreased exposure to sunlight and recurrent steroid treatment. In order to systematically evaluate bone strength we assessed 256 MS patients (171 females, 7S males) through quantitative ultrasound measurement of corticat bone. Tibial speed of sound (SOS, m/sec) was measured at midpoint of the tibial shaft using a Soundscan 2000 (Myriad Ultrasound Systems, Rehovot, Israel) and results were compared to age- and gender-matched population norms. T-score distribution in male MS patients was similar to normal population. In contrast, for female MS patients T-score distribution was significantly different from population norms, reflected by increased SOS in 30.4% (T-score intervals 1-2 and >2 above normal values; P = 0.001), compared with 74% in controls. These findings held true for both female patients younger and older than 45 years of age. Increased neurological disability and specifically motor involvement were more frequent in female patients with increased SOS (P <0.05). Bone strength was preserved in MS patients. In a subgroup of female patients increased SOS was conceivably related to spasticity.
AB - It has been previously suggested that multiple sclerosis (MS) patients are at increased risk for osteoporosis due to reduced mobility, decreased exposure to sunlight and recurrent steroid treatment. In order to systematically evaluate bone strength we assessed 256 MS patients (171 females, 7S males) through quantitative ultrasound measurement of corticat bone. Tibial speed of sound (SOS, m/sec) was measured at midpoint of the tibial shaft using a Soundscan 2000 (Myriad Ultrasound Systems, Rehovot, Israel) and results were compared to age- and gender-matched population norms. T-score distribution in male MS patients was similar to normal population. In contrast, for female MS patients T-score distribution was significantly different from population norms, reflected by increased SOS in 30.4% (T-score intervals 1-2 and >2 above normal values; P = 0.001), compared with 74% in controls. These findings held true for both female patients younger and older than 45 years of age. Increased neurological disability and specifically motor involvement were more frequent in female patients with increased SOS (P <0.05). Bone strength was preserved in MS patients. In a subgroup of female patients increased SOS was conceivably related to spasticity.
KW - Bone strength
KW - Multiple sclerosis
KW - Spasticity
KW - Speed of sound
KW - Tibial bone
UR - http://www.scopus.com/inward/record.url?scp=4444254433&partnerID=8YFLogxK
U2 - 10.1191/1352458504ms1076oa
DO - 10.1191/1352458504ms1076oa
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AN - SCOPUS:4444254433
SN - 1352-4585
VL - 10
SP - 488
EP - 493
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
IS - 5
ER -