Bone scans in the diagnosis of bone crisis in patients who have Gaucher disease

K. Katz*, S. Mechlis-Frish, I. J. Cohen, G. Horev, R. Zaizov, E. Lubin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Of thirty-four occurrences of bone pain in seventeen children and young adults who had type-I Gaucher disease, twenty-five were finally diagnosed as bone crises. On the basis of a bone scan with technetium-99m methylene diphosphonate, a correct diagnosis of bone crisis was made for twenty-three occurrences, with a sensitivity of 0.92. At the onset of a crisis, the bone scan typically showed decreased uptake of radionuclide at the involved site. After six weeks, a repeat bone scan of the long bones showed a ring of increased uptake surrounding an area of decreased uptake. At six months, the appearance of the bones on the radionuclide scan was normal.

Original languageEnglish
Pages (from-to)513-517
Number of pages5
JournalJournal of Bone and Joint Surgery - Series A
Volume73
Issue number4
DOIs
StatePublished - 1991
Externally publishedYes

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