Bone scan and bone biopsy in the detection of skeletal metastases

Ilan G. Ron*, Avi Striecker, Hedva Lerman, Amiram Bar-Am, Bertha Frisch

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


This study provides the first quantitative indication of the limits of sensitivity of a bone scan with technetium (99Tc-MDP) in detecting skeletal metastases and thereby also helps to explain the fact that bone scans may be negative when metastases are present in the bone marrow. Since 99 Tc-MDP remains the least noxious and most widely used isotope for bone scanning, these results have direct clinical relevance in the evaluation of patients with solid tumors and possible metastatic spread.

Original languageEnglish
Pages (from-to)185-188
Number of pages4
JournalOncology Reports
Issue number1
StatePublished - 1999


  • Bone marrow biopsy
  • Bone metastases
  • Bone scan


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