Bone resorption in chronic otitis media the role of mast cells

Gilead Berger, Michael Hawke*, J. Kenneth Ekem

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Twenty-two surgical specimens of eroded middle ear ossicles were removed from patients with chronic otitis media, with and without cholesteatoma. By using specific mast cell stains, increased numbers of mast cells were found in connective or granulation tissue adjacent to eroded surface of the bone. Mast cells possess the biological machinery necessary for enhancing bone resorption, and the population density of mast cells is increased in a variety of disorders that are associated with bone resorption. It is hypothesized that mast cells contribute to bone resorption in chronic otitis media, and the possible mechanisms by which mast cells exert their action are discussed.

Original languageEnglish
Pages (from-to)72-80
Number of pages9
JournalActa Oto-Laryngologica
Issue number1-2
StatePublished - 1985
Externally publishedYes


  • Bone resorption
  • Chronic otitis media
  • Mast cells


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