Bone morphogenetic protein-1: The yype I procollagen C-proteinase

Efrat Kessler*, Kazuhiko Takahara, Luba Biniaminov, Marina Brusel, Daniel S. Greenspan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Bone morphogenetic proteins (BMPs) are bone-derived factors capable of inducing ectopic bone formation. Unlike other BMPs, BMP-1 is not like transforming growth factor-β (TGF-β), but it is the prototype of a family of putative proteases implicated in pattern formation during development in diverse organisms. Although some members of this group, such as Drosophila tolloid (TLD), are postulated to activate TGF-β-like proteins, actual substrates are unknown. Procollagen C-proteinase (PCP) cleaves the COOH-propeptides of procollagens I, II, and III to yield the major fibrous components of vertebrate extracellular matrix. Here it is shown that BMP-1 and PCP are identical. This demonstration of enzymatic activity for a BMP-1/TLD-like protein links an enzyme involved in matrix deposition to genes involved in pattern formation.

Original languageEnglish
Pages (from-to)360-362
Number of pages3
Issue number5247
StatePublished - 19 Jan 1996


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