TY - JOUR
T1 - Bone growth around a metal implant inserted to the medullary canal
T2 - A new experimental model in the rat
AU - Hazan, R.
AU - Oron, U.
PY - 1991
Y1 - 1991
N2 - An experimental model for evaluation of bone growth to screw implants inserted to the medullary canal of the femur was established in rats. The kinetics of bone growth around titanium alloy (Ti6A14V) screw implants was followed using mechanical and histological measures. The force needed to pull out the screw from the femur served as an indication for the bone growth into the grooves between the ridges of the screw. A progressive and significant increase in the shear strength of the screw with time was observed from 4 until 35 days post operation. These values were 0·03±0·01, 0·24±0·05, 0·47±0·05, 1·04±0·16 and 2·13 ± 0·16 MPa at 4, 5, 6, 10 and 3 5 days after insertion of the screw implant, respectively. The general histological observation indicating progressive bone maturation next to the implants corroborated the mechanical results. The experimental model can serve as a simple and reliable model for investigation of basic aspects of bone growth to metal implants and for primary screening tests for potential implant materials.
AB - An experimental model for evaluation of bone growth to screw implants inserted to the medullary canal of the femur was established in rats. The kinetics of bone growth around titanium alloy (Ti6A14V) screw implants was followed using mechanical and histological measures. The force needed to pull out the screw from the femur served as an indication for the bone growth into the grooves between the ridges of the screw. A progressive and significant increase in the shear strength of the screw with time was observed from 4 until 35 days post operation. These values were 0·03±0·01, 0·24±0·05, 0·47±0·05, 1·04±0·16 and 2·13 ± 0·16 MPa at 4, 5, 6, 10 and 3 5 days after insertion of the screw implant, respectively. The general histological observation indicating progressive bone maturation next to the implants corroborated the mechanical results. The experimental model can serve as a simple and reliable model for investigation of basic aspects of bone growth to metal implants and for primary screening tests for potential implant materials.
UR - http://www.scopus.com/inward/record.url?scp=0025755718&partnerID=8YFLogxK
U2 - 10.1016/0267-6605(91)90056-L
DO - 10.1016/0267-6605(91)90056-L
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AN - SCOPUS:0025755718
SN - 0267-6605
VL - 7
SP - 45
EP - 49
JO - Clinical Materials
JF - Clinical Materials
IS - 1
ER -