Bone growth around a metal implant inserted to the medullary canal: A new experimental model in the rat

R. Hazan, U. Oron

Research output: Contribution to journalArticlepeer-review

Abstract

An experimental model for evaluation of bone growth to screw implants inserted to the medullary canal of the femur was established in rats. The kinetics of bone growth around titanium alloy (Ti6A14V) screw implants was followed using mechanical and histological measures. The force needed to pull out the screw from the femur served as an indication for the bone growth into the grooves between the ridges of the screw. A progressive and significant increase in the shear strength of the screw with time was observed from 4 until 35 days post operation. These values were 0·03±0·01, 0·24±0·05, 0·47±0·05, 1·04±0·16 and 2·13 ± 0·16 MPa at 4, 5, 6, 10 and 3 5 days after insertion of the screw implant, respectively. The general histological observation indicating progressive bone maturation next to the implants corroborated the mechanical results. The experimental model can serve as a simple and reliable model for investigation of basic aspects of bone growth to metal implants and for primary screening tests for potential implant materials.

Original languageEnglish
Pages (from-to)45-49
Number of pages5
JournalClinical Materials
Volume7
Issue number1
DOIs
StatePublished - 1991

Fingerprint

Dive into the research topics of 'Bone growth around a metal implant inserted to the medullary canal: A new experimental model in the rat'. Together they form a unique fingerprint.

Cite this