Bone age assessments by quantitative ultrasound (SonicBone) and hand X-ray based methods are comparable

Marianna Rachmiel*, Larisa Naugolni, Kineret Mazor-Aronovitch, Nira Koren-Morag, Tzvi Bistritzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Bone maturation is currently assessed by subjective and automated radiography. Objectives: To evaluate the concordance and reproducibility of a quantitative ultrasound (QUS) based device versus X-ray based methods. Methods: The study population comprised 150 children, 76 males, 4–17 years of age. X-ray scans were evaluated according to wrist, carpal, and phalanx areas for bone age. QUS was performed by the the BAUS™ device (SonicBone, Rishon Lezion, Israel), using speed-of-sound (SOS) and distance attenuation factor (ATN) in similar areas. Data from 100 subjects were used to establish the device conversion equation, and 50 measurements were assigned to assess inter-modality agreement. Results: BAUS showed high repeatability performance, 0.73% relative standard deviation for SOS and 3.5% for ATN. R2 for the conversion equation including gender, SOS, and ATN was 0.80 for all methods (P < 0.001). There was no significant bias in bone age assessments. Conclusions: Bone age assessment by SonicBone is comparable to the assessment by X-ray based methods.

Original languageEnglish
Pages (from-to)533-537
Number of pages5
JournalIsrael Medical Association Journal
Issue number9
StatePublished - Sep 2017


FundersFunder number
Rishon LeZion, Israel


    • BAUS™
    • Growth
    • Short stature
    • Skeletal maturation
    • SonicBone


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