Body composition in untreated adult patients with Laron syndrome (primary GH insensitivity)

Zvi Laron*, Shira Ginsberg, Pearl Lilos, Mira Arbiv, Nahum Vaisman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: To quantify body adiposity and its distribution in untreated adult patients with Laron syndrome (LS; primary GH insensitivity) caused by molecular defects of the GH receptor gene or postreceptor pathways and characterized by dwarfism, obesity, insulin resistance and hyperlipidaemia. Patients: Eleven LS patients (seven females and four males) aged 28-53 years were studied. Seven healthy males and six healthy females served as controls. Measurements: Body composition of the total body trunk, upper and lower extremities was determined using dual-energy X-ray absorptiometry (DEXA). Statistical analysis using an analysis of variance (anova) and Mann-Whitney nonparametric methods was performed separately in males and females. Results: Percentage body fat in the LS patients was much higher (P < 0.01) than that in the control population and the female LS patients were significantly more obese (59% total body fat) than the male patients (39% total body fat) (P < 0.002). It was also evident that in these types of patients with markedly increased body fat and decreased muscle and bone mass, body mass index (BMI) does not accurately reflect the body composition. Conclusions: Lifelong congenital IGF-I deficiency leads to extreme adiposity.

Original languageEnglish
Pages (from-to)114-117
Number of pages4
JournalClinical Endocrinology
Issue number1
StatePublished - Jul 2006


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