Bloodstream infections occurring in patients with percutaneously implanted bioprosthetic pulmonary valve: A single-center experience

Jonathan Buber, Lisa Bergersen, James E. Lock, Kimberlee Gauvreau, Jesse J. Esch, Michael J. Landzberg, Anne Marie Valente, Thomas J. Sandora, Audrey C. Marshall*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background-Percutaneous pulmonary valve implantation using a stent-based bioprosthetic valve provides an alternative to surgery in select patients. Systemic infections in Melody valve-implanted patients with and without identified valve involvement have been reported, yet the incidence is unknown, and risk factors remain unidentified. Methods and Results-Between 2007 and 2012, a total of 147 consecutive patients with congenital heart disease underwent Melody percutaneous pulmonary valve implantation at our institution. Demographic and clinical variables were collected at baseline and at follow-up and analyzed as predictors. The occurrence of bloodstream infection (BSI), defined as a bacterial infection treated with =4 weeks of antibiotics, served as our primary outcome. The mean age at implantation for the study population was 21.5±11 years, and tetralogy of Fallot was the cardiac condition in 59%. During a median followup of 19 months, 14 patients experienced BSI (9.5%; 95% confidence interval, 5.3%-15%). Of these, 4 (2.7%) patients had Melody valve endocarditis. Two patients died during the event, neither of whom had known valve involvement. The median procedure to infection time was 15 months (range, 1-56). In univariate analysis, male sex, previous endocarditis, in situ stents in the right ventricular outflow tract, and presence of outflow tract irregularities at the implant site were associated with BSI occurrence. Conclusions-In this cohort, 9.5% of patients who underwent Melody percutaneous pulmonary valve implantation experienced subsequent BSI, occurring 1 to 56 months after implant, and 2.7% of patients had prosthetic endocarditis. Our findings suggest that patient and nonvalve anatomic factors may be associated with BSI after percutaneous pulmonary valve implantation.

Original languageEnglish
Pages (from-to)301-310
Number of pages10
JournalCirculation: Cardiovascular Interventions
Issue number3
StatePublished - Jun 2013
Externally publishedYes


  • Congenital cardiac defect
  • Infection
  • Percutaneous valve implantation


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