Blood Transcriptional Signatures of Multiple Sclerosis: Unique Gene Expression of Disease Activity

Anat Achiron*, Michael Gurevich, Nir Friedman, Naftali Kaminski, Mathilda Mandel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Multiple sclerosis (MS) is a central nervous system disease with an unpredictable course and outcome. Peripheral blood mononuclear cells (PBMCs) are involved in the disease pathogenesis and induce active demyelination. Using oligonucleotide microarrays, we identified a statistically significant transcriptional signature of 1,109 genes in PBMCs from 26 MS patients, irrespective of disease activation state or immunomodulatory treatment. This signature contains genes that implicate underlying processes involved in MS pathogenesis including T-cell activation and expansion, inflammation, and apoptosis. Another transcriptional signature of 721 genes involved in cellular recruitment, epitope spreading, and escape from regulatory immune surveillance identified MS patients in acute relapse compared with remission. Our results offer new opportunity for understanding the mechanisms involved in MS and indicate that gene expression patterns in PBMCs contain information about a remote-target disease process that may be useful for diagnosis and future tailoring of therapeutic strategies for MS.

Original languageEnglish
Pages (from-to)410-417
Number of pages8
JournalAnnals of Neurology
Volume55
Issue number3
DOIs
StatePublished - Mar 2004

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